产品名称
R Cask Rabbit Polyclonal Antibody (Center)
别名
Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase, Cask
Human Swissprot No.
Q62915
特异性
This Rat Cask antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of rat Cask.
背景介绍
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
组织表达
Expressed in the foot process layer of podocytes in the kidney glomerulus and in tubules (at protein level). Detected in brain and neurons.
细胞定位
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
