产品名称
GRN Rabbit Polyclonal Antibody (C-term)
别名
Granulins, Proepithelin, PEPI, Acrogranin, Glycoprotein of 88 Kda, Progranulin, Paragranulin, Granulin-1, Granulin G, Granulin-2, Granulin F, Granulin-3, Granulin B, Granulin-4, Granulin A, Granulin-5, Granulin C, Granulin-6, Granulin D, Granulin-7, Granulin E, GRN
Human Gene ID
NP_002078.1
Human Swissprot No.
P28799
特异性
This GRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 563-591 amino acids from the C-terminal region of human GRN.
稀释度
IHC-P~~1:100~500;WB~~1:1000
背景介绍
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
组织表达
In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney
细胞定位
Secreted. Lysosome Note=Endocytosed by SORT1 and delivred to lysosomes (PubMed:21092856, PubMed:28073925). Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925). Co-localized with GBA in the intracellular trafficking compartments until to lysosome (By similarity) {ECO:0000250|UniProtKB:P28798, ECO:0000269|PubMed:21092856, ECO:0000269|PubMed:26370502, ECO:0000269|PubMed:28073925}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
