产品名称
MOUSE Bcar1 Rabbit Polyclonal Antibody (Center)
别名
Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, p130cas, Bcar1, Cas, Crkas
Human Swissprot No.
Q61140
Mouse Gene ID
NP_001185768.1;NP_034084.2
特异性
This MOUSE Bcar1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-348 amino acids from the Central region of mouse Bcar1.
背景介绍
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration (By similarity). Has been shown to be essential in cardiovascular development during embryogenesis.
组织表达
Expressed in olfactory sensory neurons (at protein level) (PubMed:20881139). Expressed abundantly in the liver, lung, brain, and at lower levels in the heart (at protein level) (PubMed:19365570).
细胞定位
Cell junction, focal adhesion. Cytoplasm Cell projection, axon Note=Unphosphorylated form localizes in the cytoplasm (PubMed:22801373). Localizes to focal adhesion sites following integrin engagement (PubMed:22801373).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
