产品名称
AL1A3 Rabbit Polyclonal Antibody
蛋白名称
Aldehyde dehydrogenase family 1 member A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3) (RalDH3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P47895
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P47895/entry
Mouse Swissprot No.
Q9JHW9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JHW9
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8K4D8
免疫原
Synthesized peptide derived from human protein . at AA range: 290-370
特异性
AL1A3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],
组织表达
Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.
信号通路
Glycolysis / Gluconeogenesis;Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism;
功能
catalytic activity:An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.,function:Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system.,pathway:Cofactor metabolism; retinol metabolism.,similarity:Belongs to the aldehyde dehydrogenase family.,tissue specificity:Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
