产品名称
SNX27 Rabbit Polyclonal Antibody (Center)
别名
Sorting nexin-27, SNX27, KIAA0488
Human Gene ID
NP_112180.4
Human Swissprot No.
Q96L92
特异性
This SNX27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-340 amino acids from the Central region of human SNX27.
背景介绍
SNX27 encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
组织表达
Widely expressed. Expressed in cells of hematopoietic origin (at protein level).
细胞定位
Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
