BD-PB2731-MMAA Rabbit Polyclonal Antibody (N-term)-现货抗体产品库武汉枢密脑科学技术有限公司

MMAA Rabbit Polyclonal Antibody (N-term)

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产品基本信息

产品货号

BD-PB2731

产品名称

MMAA Rabbit Polyclonal Antibody (N-term)

别名

Methylmalonic aciduria type A protein, mitochondrial, 36--, MMAA

类别

常规抗体

推荐应用

反应种属

Human, Mouse

Human Gene ID

NP_758454.1

Human Swissprot No.

Q8IVH4

特异性

This MMAA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-84 amino acids from the N-terminal region of human MMAA.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

47kDa

同种型

Rabbit Ig

背景介绍

The protein encoded by this gene is involved in the translocation of cobalamin into the mitochondrion, where it is used in the final steps of adenosylcobalamin synthesis. Adenosylcobalamin is a coenzyme required for the activity of methylmalonyl-CoA mutase. Defects in this gene are a cause of methylmalonic aciduria.

组织表达

Widely expressed. Highest expression is observed in liver and skeletal muscle

细胞定位

Mitochondrion {ECO:0000269|PubMed:28943303, ECO:0000305}. Cytoplasm

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Anti-MMAA Antibody (N-term) at 1:500 dilution + human liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 47 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Western blot analysis of MMAA Antibody (N-term) in mouse liver tissue lysates (35ug/lane). MMAA (arrow) was detected using the purified Pab.

MMAA Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded human skeletal muscle tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MMAA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.