BD-PB2720-INSC Rabbit Polyclonal Antibody (Center)-现货抗体产品库武汉枢密脑科学技术有限公司

INSC Rabbit Polyclonal Antibody (Center)

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产品基本信息

产品货号

BD-PB2720

产品名称

INSC Rabbit Polyclonal Antibody (Center)

别名

Protein inscuteable homolog, INSC

类别

常规抗体

推荐应用

反应种属

Human

Human Gene ID

NP_001027024.3;NP_001036001.1;NP_001265242.1;NP_001265243.1;NP_001265244.1;NP_001265245.1

Human Swissprot No.

Q1MX18

特异性

This INSC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-437 amino acids from the Central region of human INSC.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

63kDa

同种型

Rabbit Ig

背景介绍

In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).

组织表达

Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas.

细胞定位

Cytoplasm. Cytoplasm, cell cortex. Note=Uniformly distributed in the cytoplasm during interphase. During metaphase, detected in the cell cortex, adjacent to the mitotic spindle poles

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Western blot analysis of INSC Antibody (Center) in WiDr cell line lysates (35ug/lane). INSC (arrow) was detected using the purified Pab.

INSC Antibody (Center) IHC analysis in formalin fixed and paraffin embedded hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the INSC Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.