产品名称
ADT2 Rabbit Polyclonal Antibody
蛋白名称
ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P05141
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P05141/entry
Mouse Swissprot No.
P51881
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51881
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q09073
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
ADT2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013],
组织表达
Expressed in erythrocytes (at protein level).
细胞定位
Mitochondrion inner membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . May localize to non-mitochondrial membranes. .
信号通路
Calcium;Parkinson's disease;Huntington's disease;
功能
function:Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.,miscellaneous:The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,subunit:Homodimer. Interacts with HIV-1 Vpr.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
