产品名称
AGRIN Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O00468
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00468/entry
Mouse Swissprot No.
A2ASQ1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/A2ASQ1
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P25304
免疫原
Synthesized peptide derived from human protein . at AA range: 1900-1980
特异性
AGRIN Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015],
组织表达
Expressed in basement membranes of lung and kidney. Muscle- and neuron-specific isoforms are found. Isoforms (y+) with the 4 AA insert and (z+8) isoforms with the 8 AA insert are all neuron-specific. Isoforms (z+11) are found in both neuronal and non-neuronal tissues.
细胞定位
[Isoform 1]: Secreted, extracellular space, extracellular matrix . Synaptic basal lamina at the neuromuscular junction. .; [Isoform 2]: Cell junction, synapse . Cell membrane ; Single-pass type II membrane protein .
信号通路
ECM-receptor interaction;
功能
function:Component of the basal lamina that causes the aggregation of acetylcholine receptors and acetylcholine-esterase on the surface of muscle fibers of the neuromuscular junction.,PTM:Contains heparan sulfate chains as well as N-linked and O-linked oligosaccharides.,similarity:Contains 1 NtA (N-terminal agrin) domain.,similarity:Contains 1 SEA domain.,similarity:Contains 2 laminin EGF-like domains.,similarity:Contains 3 laminin G-like domains.,similarity:Contains 4 EGF-like domains.,similarity:Contains 9 Kazal-like domains.,subcellular location:Synaptic basal lamina at the neuromuscular junction.,subunit:Binds to laminin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
