产品名称
AFF4 Rabbit Polyclonal Antibody
基因名称
AFF4 AF5Q31 MCEF HSPC092
蛋白名称
AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UHB7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UHB7/entry
Mouse Swissprot No.
Q9ESC8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9ESC8
免疫原
Synthesized peptide derived from human protein . at AA range: 30-110
特异性
AFF4 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011],
组织表达
Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain.
细胞定位
Nucleus . Associates to transcriptionally active chromatin but not at snRNA genes. .
功能
developmental stage:Expressed in fetal heart, lung, brain and to a lower extent liver.,disease:A chromosomal aberration involving AFF4 is found in acute lymphoblastic leukemia (ALL). Insertion ins(5;11)(q31;q13q23) that forms a MLL-AFF4 fusion protein.,function:May play a role in transcriptional regulation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the AF4 family.,subunit:Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb).,tissue specificity:Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
