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DUSP13-M1 Rabbit Polyclonal Antibody (N-term)

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产品基本信息

产品货号
BD-PB2591
产品名称
DUSP13-M1 Rabbit Polyclonal Antibody (N-term)
别名
Dual specificity protein phosphatase 13 isoform B, DUSP13B, Dual specificity phosphatase SKRP4, Testis- and skeletal-muscle-specific DSP, DUSP13, DUSP13B, TMDP
类别
常规抗体
推荐应用
WB
反应种属
Human
Human Gene ID
NP_057448.3
Human Swissprot No.
Q9UII6
特异性
This DUSP13-M1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DUSP13-M1.
稀释度
WB~~1:1000;IHC-P~~1:100~500
预测分子量
22kDa
同种型
Rabbit Ig
背景介绍
Dual-specificity phosphatases, a subfamily of protein-tyrosine phosphatases, play important roles in signal transduction, cell cycle progression, and tumor suppression. The cDNA encoding a novel phosphatase, PIR1, phosphatase that interacts with RNA/RNP complex 1. Sequence analysis revealed that the predicted 329-amino acid protein has homology to several dual-specificity phosphatases and contains 2 stretches of arginine-rich sequence similar to those found in some RNA-binding proteins. In vitro, recombinant protein displays protein-tyrosine phosphatase activity and binds directly to RNA.
组织表达
Highly expressed in the testis (at protein level) (PubMed:10585869, PubMed:15252030). Also found in the skeletal muscle (PubMed:15252030).
期货
现货
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Western blot analysis of DUSP13 (arrow) using DUSP13-M1 Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DUSP13 gene (Lane 2) .

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

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