BD-PB2581

NME4 Rabbit Polyclonal Antibody (N-term)

Nucleoside diphosphate kinase, mitochondrial, NDK, NDP kinase, mitochondrial, Nucleoside diphosphate kinase D, NDPKD, nm23-H4, NME4, NM23D

常规抗体

WB

Human

NP_005000.1

O00746

This NME4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NME4.

IHC-P~~1:100~500;WB~~1:1000

21kDa

Rabbit Ig

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes

Mitochondrion intermembrane space; Peripheral membrane protein Mitochondrion matrix. Note=Predominantly localized in the mitochondrion intermembrane space (PubMed:18635542) Colocalizes with OPA1 in mitochondria (PubMed:24970086)

现货

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.