产品名称
ADA23 Rabbit Polyclonal Antibody
蛋白名称
Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75077
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75077/entry
Mouse Swissprot No.
Q9R1V7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R1V7
免疫原
Synthesized peptide derived from human protein . at AA range: 720-800
特异性
ADA23 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
ADAM metallopeptidase domain 23(ADAM23) Homo sapiens This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013],
组织表达
Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
细胞定位
Cell membrane ; Single-pass type I membrane protein .; [Isoform Gamma]: Secreted.
功能
developmental stage:Highly expressed in the fetal brain.,domain:A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.,function:May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,subunit:Ligand for integrin alpha-V/beta-3.,tissue specificity:Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
