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TYRO3 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PB2536
产品名称
TYRO3 Rabbit Polyclonal Antibody
别名
Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase BYK, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase SKY, Tyrosine-protein kinase TIF, TYRO3, BYK, DTK, RSE, SKY, TIF
类别
常规抗体
推荐应用
WB
反应种属
Human
Human Gene ID
NP_006284.2
Human Swissprot No.
Q06418
特异性
This TYRO3 antibody is generated from rabbits immunized with human recombinant TYRO3 protein.
稀释度
WB~~1:1000;IHC-P~~1:100~500
预测分子量
97kDa
同种型
Rabbit Ig
背景介绍
Tyrosine kinase 3,mainly expressed in brain,is involved in the protection of neurons from apoptosis. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
组织表达
Abundant in the brain and lower levels in other tissues
细胞定位
Cell membrane; Single-pass type I membrane protein
期货
现货
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Western blot analysis of lysate from U-87 MG cell line, using TYRO3 Antibodyat 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

Formalin-fixed and paraffin-embedded human brain tissue reacted with TYRO3 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

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