BD-PB2509-CAMK2A Rabbit Polyclonal Antibody (C-term E370)-现货抗体产品库武汉枢密脑科学技术有限公司

CAMK2A Rabbit Polyclonal Antibody (C-term E370)

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产品基本信息

产品货号

BD-PB2509

产品名称

CAMK2A Rabbit Polyclonal Antibody (C-term E370)

别名

Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, CAMK2A, CAMKA, KIAA0968

类别

常规抗体

推荐应用

反应种属

Human

Human Gene ID

NP_741960.1

Human Swissprot No.

Q9UQM7

特异性

This CAMK2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-371 amino acids from the C-terminal region of human CAMK2A.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

54kDa

同种型

Rabbit Ig

背景介绍

CAMK2A belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by the gene for CAMK2A is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity.

细胞定位

Cell junction, synapse {ECO:0000250|UniProtKB:P11275}. Cell junction, synapse, postsynaptic density {ECO:0000250|UniProtKB:P11275}. Cell projection, dendritic spine. Cell projection, dendrite. Note=Postsynaptic lipid rafts {ECO:0000250|UniProtKB:P11275}

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Western blot analysis of anti-CAMK2A Antibody (C-term E370) in 293 cell line lysates (35ug/lane). CAMK2A(arrow) was detected using the purified Pab.

Western blot analysis of CAMK2A (arrow) using rabbit polyclonal CAMK2A Antibody (C-term E370) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CAMK2A gene (Lane 2).

Formalin-fixed and paraffin-embedded human brain tissue reacted with CAMK2A (C-term E370) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.