产品名称
ACOX2 Rabbit Polyclonal Antibody
蛋白名称
Peroxisomal acyl-coenzyme A oxidase 2 (EC 1.17.99.3) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase) (Trihydroxycoprostanoyl-CoA oxidase) (THCA-CoA oxidase) (THCCox)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q99424
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99424/entry
Mouse Swissprot No.
Q9QXD1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QXD1
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P97562
免疫原
Synthesized peptide derived from human protein . at AA range: 270-350
特异性
ACOX2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009],
组织表达
Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney.
信号通路
Primary bile acid biosynthesis;PPAR;
功能
catalytic activity:(25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oyl-CoA + H(2)O + acceptor = (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor.,cofactor:FAD.,disease:Absent in patients suffering from Zellweger syndrome.,function:Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.,similarity:Belongs to the acyl-CoA oxidase family.,subunit:Heterodimer.,tissue specificity:Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
