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PANK1 Rabbit Polyclonal Antibody (Center)

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产品基本信息

产品货号
BD-PB2478
产品名称
PANK1 Rabbit Polyclonal Antibody (Center)
别名
Pantothenate kinase 1, hPanK, hPanK1, Pantothenic acid kinase 1, PANK1, PANK
类别
常规抗体
推荐应用
WB
反应种属
Human
Human Gene ID
NP_612189.2;NP_683878.1;NP_683879.1
Human Swissprot No.
Q8TE04
特异性
This PANK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-360 amino acids from the Central region of human PANK1.
稀释度
WB~~1:1000;IHC-P~~1:100~500
预测分子量
64kDa
同种型
Rabbit Ig
背景介绍
PANK1 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA.
组织表达
[Isoform 1]: Expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis
细胞定位
Cytoplasm. [Isoform 2]: Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome
期货
现货
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Western blot analysis of anti-PANK1 Pab in mouse kidney tissue lysate (35ug/lane). PANK1(arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

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