BD-PB2448-SFRS1 Rabbit Polyclonal Antibody (N-term)-现货抗体产品库武汉枢密脑科学技术有限公司

SFRS1 Rabbit Polyclonal Antibody (N-term)

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产品基本信息

产品货号

BD-PB2448

产品名称

SFRS1 Rabbit Polyclonal Antibody (N-term)

别名

Serine/arginine-rich splicing factor 1, Alternative-splicing factor 1, ASF-1, Splicing factor, arginine/serine-rich 1, pre-mRNA-splicing factor SF2, P33 subunit, SRSF1, ASF, SF2, SF2P33, SFRS1

类别

常规抗体

推荐应用

反应种属

Human

Human Gene ID

NP_001071634.1;NP_008855.1

Human Swissprot No.

Q07955

特异性

This SFRS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-38 amino acids from the N-terminal region of human SFRS1.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

28kDa

同种型

Rabbit Ig

背景介绍

SFRS1 is a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins.

细胞定位

Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm (PubMed:12215544, PubMed:20308322, PubMed:9420331, PubMed:24449914) Nuclear import is mediated via interaction with TNPO3 (PubMed:24449914).

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Western blot analysis of SFRS1 Antibody (N-term) in A2058, WiDr cell line lysates (35ug/lane). SFRS1 (arrow) was detected using the purified Pab.

SFRS1 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SFRS1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Western blot analysis of SFRS1 (arrow) using rabbit polyclonal SFRS1 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SFRS1 gene.