BD-PB2418-MTBP Rabbit Polyclonal Antibody (C-term)-现货抗体产品库武汉枢密脑科学技术有限公司

MTBP Rabbit Polyclonal Antibody (C-term)

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产品基本信息

产品货号

BD-PB2418

产品名称

MTBP Rabbit Polyclonal Antibody (C-term)

别名

Mdm2-binding protein, hMTBP, MTBP

类别

常规抗体

推荐应用

反应种属

Human

Human Gene ID

NP_071328.2

Human Swissprot No.

Q96DY7

特异性

This MTBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 853-881 amino acids from the C-terminal region of human MTBP.

稀释度

WB~~1:1000;IHC-P~~1:100~500;FC~~1:10~50

预测分子量

102kDa

同种型

Rabbit Ig

背景介绍

MTBP inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. The protein may play a role in MDM2-dependent TP53/p53 homeostasis in unstressed cells. The protein inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of TP53/p53 and its subsequent degradation.

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Western blot analysis of MTBP antibody (C-term) in K562 cell line lysates (35ug/lane). MTBP (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with MTBP Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Flow cytometric analysis of K562 cells using MTBP Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.