产品名称
TBRG1 Rabbit Polyclonal Antibody (N-term)
别名
Transforming growth factor beta regulator 1, Nuclear interactor of ARF and Mdm2, TBRG1, NIAM
Human Gene ID
NP_116200.2
Human Swissprot No.
Q3YBR2
特异性
This TBRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-36 amino acids from the N-terminal region of human TBRG1.
背景介绍
TBRG1 acts as a growth inhibitor. It can activate TP53/p53, cause G1 arrest and collaborate with CDKN2A to restrict proliferation, but it does not require either protein to inhibit DNA synthesis. TBRG1 redistributes CDKN2A into the nucleoplasm, and is involved in maintaining chromosomal stability.
组织表达
Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B- cell lymphoma.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
