BD-PB2387-Kallikrein 7 Rabbit Polyclonal Antibody (Center)-现货抗体产品库武汉枢密脑科学技术有限公司

Kallikrein 7 Rabbit Polyclonal Antibody (Center)

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产品基本信息

产品货号

BD-PB2387

产品名称

Kallikrein 7 Rabbit Polyclonal Antibody (Center)

别名

Kallikrein-7, hK7, Serine protease 6, Stratum corneum chymotryptic enzyme, hSCCE, KLK7, PRSS6, SCCE

类别

常规抗体

推荐应用

反应种属

Human

Human Gene ID

NP_001193982.1;NP_001230055.1;NP_005037.1;NP_644806.1

Human Swissprot No.

P49862

特异性

This Kallikrein 7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-97 amino acids from the Central region of human Kallikrein 7.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

28kDa

同种型

Rabbit Ig

背景介绍

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The KLK7 enzyme is thought to be involved in the proteolysis of intercellular cohesive structures preceding desquamation, which is the shedding of the outermost layer of the epidermis.

组织表达

Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up- regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level)

细胞定位

Secreted. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Anti-KLK7-S82 at 1:2000 dilution + TT whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 28 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

KLK7 Antibody (S82) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the KLK7 antibody detected the KLK7 protein (arrow).

Kallikrein 7(KLK7) Antibody (Center)immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Kallikrein 7(KLK7) Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.