产品名称
TCF4 Rabbit Polyclonal Antibody (N-term)
别名
Transcription factor 4, TCF-4, Class B basic helix-loop-helix protein 19, bHLHb19, Immunoglobulin transcription factor 2, ITF-2, SL3-3 enhancer factor 2, SEF-2, TCF4, BHLHB19, ITF2, SEF2
Human Gene ID
NP_001077431.1;NP_001230155.1;NP_001230156.1;NP_001230157.1;NP_001230159.1;NP_001230160.1;NP_001230161.1;NP_001230162.1;NP_001230163.1;NP_001230164.1;NP_001230165.1;NP_003190.1
Human Swissprot No.
P15884
特异性
This TCF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-73 amino acids from the N-terminal region of human TCF4.
背景介绍
TCF4 is transcription factor 4, a basic
helix-turn-helix transcription factor. The encoded protein
recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a
motif first identified in immunoglobulin enhancers. This gene is
expressed predominantly in pre-B-cells, although it is found in
other tissues as well. Defects in this gene are a cause of
Pitt-Hopkins syndrome.
组织表达
Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:22777675}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
