产品名称
RL7A Rabbit Polyclonal Antibody
蛋白名称
60S ribosomal protein L7a (PLA-X polypeptide) (Surfeit locus protein 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P62424
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P62424/entry
Mouse Swissprot No.
P12970
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P12970
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P62425
免疫原
Synthesized peptide derived from human protein . at AA range: 180-260
特异性
RL7A Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene t
组织表达
B-cell,Cerebellum,Eye,Lung,Placenta,Pooled,Skin,Uterus,
细胞定位
nucleus,nucleolus,cytoplasm,cytosol,ribosome,cell-cell adherens junction,focal adhesion,membrane,cytosolic large ribosomal subunit,polysomal ribosome,extracellular exosome,
功能
disease:Chromosomal recombination involving RPL7A activates the receptor kinase domain of the TRK oncogene.,similarity:Belongs to the ribosomal protein L7Ae family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
