BD-PB2310-PREPL Rabbit Polyclonal Antibody (C-term)-现货抗体产品库武汉枢密脑科学技术有限公司

PREPL Rabbit Polyclonal Antibody (C-term)

产品详情相关文献产品问答相关产品

产品基本信息

产品货号

BD-PB2310

产品名称

PREPL Rabbit Polyclonal Antibody (C-term)

别名

Prolyl endopeptidase-like, 3421-, Prolylendopeptidase-like, PREPL, KIAA0436

类别

常规抗体

推荐应用

反应种属

Human, Hamster, Mouse

Human Gene ID

NP_001035844.1;NP_001035845.1;NP_001165074.1;NP_001165077.1;NP_001165084.1;NP_001165088.1;NP_006027.2

Human Swissprot No.

Q4J6C6

特异性

This PREPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-652 amino acids from the C-terminal region of human PREPL.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

84kDa

同种型

Rabbit Ig

背景介绍

The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome.

组织表达

Expressed in pyramidal neurons of the temporal cortex and neocortex (at protein level) (PubMed:23485813). Widely expressed (PubMed:15913950, PubMed:16385448). Expressed at higher level in brain, skeletal muscle, heart and kidney (PubMed:15913950, PubMed:16385448). Expressed at the endplates in the neuromuscular junction (PubMed:24610330).

细胞定位

Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8C167}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8C167}. Golgi apparatus {ECO:0000250|UniProtKB:Q8C167}. Nucleus Note=Co-localizes with AP-1 in the trans-Golgi network (By similarity) Co-localizes with MAP2 and ACTB on the cytoskeleton (By similarity) Co-localizes with STX6 and GOSR2 at the Golgi apparatus (By similarity). {ECO:0000250|UniProtKB:Q8C167}

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

PREPL Antibody (C-term) western blot analysis in CHO cell line lysates (15ug/lane).This demonstrates the PREPL antibody detected the PREPL protein (arrow).

PREPL Antibody (C-term) western blot analysis in mouse stomach tissue lysates (15ug/lane).This demonstrates the PREPL antibody detected the PREPL protein (arrow).

PREPL Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PREPL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.