BD-PB2299-IPO7 Rabbit Polyclonal Antibody (N-term)-现货抗体产品库武汉枢密脑科学技术有限公司

IPO7 Rabbit Polyclonal Antibody (N-term)

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产品基本信息

产品货号

BD-PB2299

产品名称

IPO7 Rabbit Polyclonal Antibody (N-term)

别名

Importin-7, Imp7, Ran-binding protein 7, RanBP7, IPO7, RANBP7

类别

常规抗体

推荐应用

反应种属

Human, Mouse

Human Gene ID

NP_006382.1

Human Swissprot No.

O95373

特异性

This IPO7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-169 amino acids from the N-terminal region of human IPO7.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

120kDa

同种型

Rabbit Ig

背景介绍

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.

细胞定位

Cytoplasm. Nucleus.

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Anti-IPO7 Antibody (N-term) at 1:1000 dilution + Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 120 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

IPO7 Antibody (N-term)western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the IPO7 antibody detected the IPO7 protein (arrow).

IPO7 Antibody (N-term)western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the IPO7 antibody detected the IPO7 protein (arrow).

IPO7 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CRABP1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.