产品名称
AXIN2 Rabbit Polyclonal Antibody (C-term)
别名
Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin, AXIN2
Human Gene ID
NP_004646.3
Human Swissprot No.
Q9Y2T1
特异性
This AXIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of human AXIN2.
背景介绍
The Axin-related protein, Axin2, presumably plays an
important role in the regulation of the stability of beta-catenin
in the Wnt signaling pathway, like its rodent homologs, mouse
conductin/rat axil. In mouse, conductin organizes a multiprotein
complex of APC (adenomatous polyposis of the colon), beta-catenin,
glycogen synthase kinase 3-beta, and conductin, which leads to the
degradation of beta-catenin. Apparently, the deregulation of
beta-catenin is an important event in the genesis of a number of
malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region
that shows frequent loss of heterozygosity in breast cancer,
neuroblastoma, and other tumors. Mutations in this gene have been
associated with colorectal cancer with defective mismatch repair.
组织表达
Expressed in brain and lymphoblast.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
