BD-PB2255-UBXN6 Rabbit Polyclonal Antibody (C-term)-现货抗体产品库武汉枢密脑科学技术有限公司

UBXN6 Rabbit Polyclonal Antibody (C-term)

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产品基本信息

产品货号

BD-PB2255

产品名称

UBXN6 Rabbit Polyclonal Antibody (C-term)

别名

UBX domain-containing protein 6, UBX domain-containing protein 1, UBXN6, UBXD1, UBXDC2

类别

常规抗体

推荐应用

反应种属

Human, Mouse

Human Gene ID

NP_001164562.1;NP_079517.1

Human Swissprot No.

Q9BZV1

特异性

This UBXN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-309 amino acids from the C-terminal region of human UBXN6.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

50kDa

同种型

Rabbit Ig

背景介绍

UBXN6 acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. UBXN6 is MDM2 stabilization leads to MDM2-dependent TP53 degradation.

组织表达

Enhanced expression in testis.

细胞定位

Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Early endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Note=Localizes at the centrosome both in interphase and during mitosis (PubMed:18656546). May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP (PubMed:21822278). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622)

期货

现货

纯化

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Anti-UBXN6 Antibody (C-term) at 1:2000 dilution + Human testis lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 50 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Western blot analysis of UBXN6 Antibody (C-term) in mouse kidney tissue lysates (35ug/lane).UBXN6 (arrow) was detected using the purified Pab.

UBXN6 Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded mouse testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the UBXN6 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.