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BBS10 Rabbit Polyclonal Antibody (C-term)

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产品基本信息

产品货号
BD-PB2229
产品名称
BBS10 Rabbit Polyclonal Antibody (C-term)
别名
Bardet-Biedl syndrome 10 protein, BBS10, C12orf58
类别
常规抗体
推荐应用
WB
反应种属
Human
Human Gene ID
NP_078961.3
Human Swissprot No.
Q8TAM1
特异性
This BBS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 515-544 amino acids from the C-terminal region of human BBS10.
稀释度
WB~~1:1000;FC~~1:10~50
预测分子量
81kDa
同种型
Rabbit Ig
背景介绍
BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.
细胞定位
Cell projection, cilium. Note=Located within the basal body of the primary cilium of differentiating preadipocytes
期货
现货
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Western blot analysis of BBS10 Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane). BBS10 (arrow) was detected using the purified Pab.

BBS10 Antibody (C-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

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