产品名称
SPNXB Rabbit Polyclonal Antibody (Center)
别名
Sperm protein associated with the nucleus on the X chromosome B/F, Cancer/testis antigen 112, CT112, Nuclear-associated protein SPAN-Xb, SPANX-B, Nuclear-associated protein SPAN-Xf, SPANX-F, SPANX family member B/F, SPANXB1, SPANXB
Human Gene ID
NP_115850.1;NP_620588.1;NP_663697.1
Human Swissprot No.
Q9NS25
特异性
This SPNXB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 amino acids from the Central region of human SPNXB.
背景介绍
Temporally regulated transcription and translation of
several testis-specific genes is required to initiate the series of
molecular and morphological changes in the male germ cell lineage
necessary for the formation of mature spermatozoa. This gene is a
member of the SPANX family of cancer/testis-associated genes, which
are located in a cluster on chromosome X. The SPANX genes encode
differentially expressed testis-specific proteins that localize to
various subcellular compartments. This particular gene maps to
chromosome X in a head-to-tail orientation with SPANX family member
B1 and appears to be a duplication of that locus. The SPANXB genes
are unique members of this gene family, since they contain an
additional 18 nt in their coding region compared to the majority of
family members. Although the protein encoded by this gene contains
consensus nuclear localization signals, the major site for
subcellular localization of expressed protein is in the cytoplasmic
droplets of ejaculated spermatozoa. This protein provides a
biochemical marker for studying the unique structures in
spermatazoa, while attempting to further define its role in
spermatogenesis.
组织表达
Detected in testis and sperm.
细胞定位
Cytoplasm. Nucleus. Note=Associated with nuclear craters
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
