产品名称
GEMIN4 Rabbit Polyclonal Antibody (N-term)
别名
Gem-associated protein 4, Gemin-4, Component of gems 4, p97, GEMIN4
Human Gene ID
NP_056536.2
Human Swissprot No.
P57678
特异性
This GEMIN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-301 amino acids from the N-terminal region of human GEMIN4.
背景介绍
The product of this gene is part of a large complex
localized to the cytoplasm, nucleoli, and to discrete nuclear
bodies called Gemini bodies (gems). The complex functions in
spliceosomal snRNP assembly in the cytoplasm, and regenerates
spliceosomes required for pre-mRNA splicing in the nucleus. The
encoded protein directly interacts with a DEAD box protein and
several spliceosome core proteins. Alternatively spliced transcript
variants have been described, but their biological validity has not
been determined.
细胞定位
Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs and in the nucleolus
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
