产品名称
RRM1 Rabbit Polyclonal Antibody (N-term)
别名
Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RRM1, RR1
Human Gene ID
NP_001024.1
Human Swissprot No.
P23921
特异性
This RRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human RRM1.
背景介绍
This gene encodes one of two non-identical subunits that
constitute ribonucleoside-diphosphate reductase, an enzyme
essential for the production of deoxyribonucleotides prior to DNA
synthesis in S phase of dividing cells. It is one of several genes
located in the imprinted gene domain of 11p15.5, an important
tumor-suppressor gene region. Alterations in this region have been
associated with the Beckwith-Wiedemann syndrome, Wilms tumor,
rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and
breast cancer. This gene may play a role in malignancies and
disease that involve this region.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
