产品名称
SF3A2 Rabbit Polyclonal Antibody (Center)
别名
Splicing factor 3A subunit 2, SF3a66, Spliceosome-associated protein 62, SAP 62, SF3A2, SAP62
Human Gene ID
NP_009096.2
Human Swissprot No.
Q15428
特异性
This SF3A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the Central region of human SF3A2.
背景介绍
This gene encodes subunit 2 of the splicing factor 3a
protein complex. The splicing factor 3a heterotrimer includes
subunits 1, 2 and 3 and is necessary for the in vitro conversion of
15S U2 snRNP into an active 17S particle that performs pre-mRNA
splicing. Subunit 2 interacts with subunit 1 through its
amino-terminus while the single zinc finger domain of subunit 2
plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also
function independently of its RNA splicing function as a
microtubule-binding protein.
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00130, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:21349847, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
