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KCNA4 Rabbit Polyclonal Antibody (C-term)

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产品基本信息

产品货号
BD-PB2000
产品名称
KCNA4 Rabbit Polyclonal Antibody (C-term)
别名
Potassium voltage-gated channel subfamily A member 4, HPCN2, Voltage-gated K(+) channel HuKII, Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, Voltage-gated potassium channel subunit Kv14, KCNA4, KCNA4L
类别
常规抗体
推荐应用
WB
反应种属
Human
Human Gene ID
NP_002224.1
Human Swissprot No.
P22459
特异性
This KCNA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-619 amino acids from the C-terminal region of human KCNA4.
稀释度
WB~~1:1000
预测分子量
73kDa
同种型
Rabbit Ig
背景介绍
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
组织表达
Expressed in brain, and at lower levels in the testis, lung, kidney, colon and heart (PubMed:27582084). Detected in heart ventricle.
细胞定位
Cell membrane; Multi-pass membrane protein Cell projection, axon {ECO:0000250|UniProtKB:P15385}
期货
现货
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

KCNA4 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KCNA4 antibody detected the KCNA4 protein (arrow).

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