产品名称
CASQ2 Rabbit Polyclonal Antibody (Center)
别名
Calsequestrin-2, Calsequestrin, cardiac muscle isoform, CASQ2
Human Gene ID
NP_001223.2
Human Swissprot No.
O14958
特异性
This CASQ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the Central region of human CASQ2.
背景介绍
The protein encoded by this gene specifies the cardiac
muscle family member of the calsequestrin family. Calsequestrin is
localized to the sarcoplasmic reticulum in cardiac and slow
skeletal muscle cells. The protein is a calcium binding protein
that stores calcium for muscle function. Mutations in this gene
cause stress-induced polymorphic ventricular tachycardia, also
referred to as catecholaminergic polymorphic ventricular
tachycardia 2 (CPVT2), a disease characterized by bidirectional
ventricular tachycardia that may lead to cardiac arrest. [provided
by RefSeq].
细胞定位
Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:O09161}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells {ECO:0000250|UniProtKB:O09161}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
