产品名称
PDCD6 Rabbit Polyclonal Antibody (N-term)
别名
Programmed cell death protein 6, Apoptosis-linked gene 2 protein, Probable calcium-binding protein ALG-2, PDCD6, ALG2
Human Gene ID
NP_001254485.1;NP_001254486.1;NP_001254487.1;NP_001254488.1;NP_037364.1
Human Swissprot No.
O75340
特异性
This PDCD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the N-terminal region of human PDCD6.
背景介绍
This gene encodes a calcium-binding protein belonging to
the penta-EF-hand protein family. Calcium binding is important for
homodimerization and for conformational changes required for
binding to other protein partners. This gene product participates
in T cell receptor-, Fas-, and glucocorticoid-induced programmed
cell death. In mice deficient for this gene product, however,
apoptosis was not blocked suggesting this gene product is
functionally redundant.
细胞定位
Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane. Cytoplasm. Nucleus. Endosome Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus (PubMed:17045351). Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules (PubMed:21122810). In response to calcium increase, relocates from cytoplasm to COPII vesicle coat (PubMed:27716508) Localizes to endoplasmic reticulum exit site (ERES) (PubMed:27813252)
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
