产品名称
EBAG9 Rabbit Polyclonal Antibody (Center)
别名
Receptor-binding cancer antigen expressed on SiSo cells, Cancer-associated surface antigen RCAS1, Estrogen receptor-binding fragment-associated gene 9 protein, EBAG9, RCAS1
Human Gene ID
NP_001265867.1;NP_004206.1;NP_936056.1
Human Swissprot No.
O00559
特异性
This EBAG9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human EBAG9.
背景介绍
This gene was identified as an estrogen-responsive gene.
Regulation of transcription by estrogen is mediated by estrogen
receptor which binds to the estrogen-responsive element (ERE) found
in the 5'-flanking region of this gene. The encoded protein is a
tumor-associated antigen that is expressed at high frequency in a
variety of cancers. Two transcript variants differing in the 5'
UTR, but encoding the same protein, have been identified for this
gene.
组织表达
Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs
细胞定位
Golgi apparatus membrane; Single-pass type III membrane protein. Note=According to PubMed:10426319, it also exists as a soluble form which has the same biological activities The existence of such soluble form is however uncertain
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
