产品名称
MMP26 Rabbit Polyclonal Antibody (Center)
别名
Matrix metalloproteinase-26, MMP-26, 3424-, Endometase, Matrilysin-2, MMP26
Human Gene ID
NP_068573.2
Human Swissprot No.
Q9NRE1
特异性
This MMP26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-125 amino acids from the Central region of human MMP26.
背景介绍
Proteins of the matrix metalloproteinase (MMP) family are
involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development,
reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP's are
secreted as inactive proproteins which are activated when cleaved
by extracellular proteinases. The encoded protein degrades type IV
collagen, fibronectin, fibrinogen, casein, vitronectin, alpha
1-antitrypsin, alpha 2-macroglobulin, and insulin-like growth
factor-binding protein 1, and activates MMP9 by cleavage. The
protein differs from most MMP family members in that it lacks a
conserved C-terminal protein domain.
组织表达
Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines
细胞定位
Secreted, extracellular space, extracellular matrix
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
