产品名称
LIN7B Rabbit Polyclonal Antibody (N-term)
别名
Protein lin-7 homolog B, Lin-7B, hLin7B, Mammalian lin-seven protein 2, MALS-2, Vertebrate lin-7 homolog 2, Veli-2, hVeli2, LIN7B, MALS2, VELI2
Human Gene ID
NP_071448.1
Human Swissprot No.
Q9HAP6
特异性
This LIN7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human LIN7B.
背景介绍
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).
细胞定位
Cell membrane {ECO:0000250|UniProtKB:O88951}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Basolateral cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Cell junction {ECO:0000250|UniProtKB:O88951}. Cell junction, synapse, postsynaptic density membrane {ECO:0000250|UniProtKB:O88951}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Cell junction, tight junction {ECO:0000250|UniProtKB:O88951}. Note=Mainly basolateral in renal epithelial cells.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
