产品名称
Mouse Krt6a Rabbit Polyclonal Antibody(Center)
别名
Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Keratin-6-alpha, mK6-alpha, Keratin-6A, K6A, Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6
Human Swissprot No.
P50446
Mouse Gene ID
NP_032502.3
特异性
This Mouse Krt6a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of mouse Krt6a.
背景介绍
Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation related keratins). Keratin 6 is found in hair follicles, neck squamous cell carcinomas, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation. There are at least six isoforms of human type II keratin 6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.
组织表达
Predominates in the adult trunk skin, tongue, trachea/esophagus and eye. In adult skin, localization is restricted to hair follicles, where it is localized predominantly in the outer root sheath.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
