产品名称
DPEP1 Rabbit Polyclonal Antibody(N-term)
别名
Dipeptidase 1, Dehydropeptidase-I, Microsomal dipeptidase, Renal dipeptidase, hRDP, DPEP1, MDP, RDP
Human Gene ID
NP_001121613.1;NP_004404.1
Human Swissprot No.
P16444
特异性
This DPEP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DPEP1.
背景介绍
DPEP1 (EC 3.4.13.11) is a kidney membrane enzyme that
hydrolyzes a variety of dipeptides and is implicated in renal
metabolism of glutathione and its conjugates, e.g., leukotriene D4
(Kozak and Tate, 1982 [PubMed 6122685]). DPEP1 is responsible for
hydrolysis of the beta-lactam ring of antibiotics, such as penem
and carbapenem (Campbell et al., 1984 [PubMed 6334084]). Earlier,
beta-lactamase enzymes were thought to occur only in bacteria,
where their probable function was in protecting the organisms
against the action of beta-lactam antibiotics. These antibiotics
exhibit selective toxicity against bacteria but virtual inertness
against many eukaryotic cells (Adachi et al., 1990 [PubMed
2303490]).
组织表达
Expressed in lung and kidneys.
细胞定位
Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI-anchor. Note=Brush border membrane {ECO:0000250|UniProtKB:P31429}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
