产品名称
USH1C Rabbit Polyclonal Antibody(N-term)
别名
Harmonin, Antigen NY-CO-38/NY-CO-37, Autoimmune enteropathy-related antigen AIE-75, Protein PDZ-73, Renal carcinoma antigen NY-REN-3, Usher syndrome type-1C protein, USH1C, AIE75
Human Gene ID
NP_005700.2;NP_710142.1
Human Swissprot No.
Q9Y6N9
特异性
This USH1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human USH1C.
背景介绍
This gene encodes a scaffold protein that functions in the
assembly of Usher protein complexes. The protein contains PDZ
domains, a coiled-coil region with a bipartite nuclear localization
signal and a PEST degradation sequence. Defects in this gene are
the cause of Usher syndrome type 1C and non-syndromic sensorineural
deafness autosomal recessive type 18. Multiple transcript variants
encoding different isoforms have been found for this gene.
组织表达
Expressed in small intestine, colon, kidney, eye and weakly in pancreas. Expressed also in vestibule of the inner ear
细胞定位
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, microvillus. Note=Colocalizes with F-actin (By similarity). Detected at the tip of cochlear hair cell stereocilia (By similarity). Enriched in microvilli of the intestinal brush border (PubMed:24725409). {ECO:0000250|UniProtKB:Q9ES64, ECO:0000269|PubMed:24725409}
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
