产品名称
RAET1E Rabbit Polyclonal Antibody(Center)
别名
NKG2D ligand 4, N2DL-4, NKG2DL4, Lymphocyte effector toxicity activation ligand, RAE-1-like transcript 4, RL-4, Retinoic acid early transcript 1E, RAET1E, LETAL, N2DL4, ULBP4
Human Gene ID
NP_001230254.1;NP_001230256.1;NP_001230257.1;NP_631904.1
Human Swissprot No.
Q8TD07
特异性
This RAET1E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-179 amino acids from the Central region of human RAET1E.
背景介绍
Members of the RAET1 family, such as RAET1E, are major
histocompatibility complex (MHC) class I-related genes located
within a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins
contain MHC class I-like alpha-1 and alpha-2 domains. RAET1E and
RAET1G (MIM 609244) differ from the other RAET1 proteins (e.g.,
RAET1I, or ULBP1; MIM 605697) in that they have type I
membrane-spanning sequences at their C termini rather than
glycosylphosphatidylinositol anchor sequences. RAET1E is a ligand
for NKG2D (KLRK1; MIM 611817), which is expressed on the surface of
several types of immune cells and is involved in innate and
adaptive immune responses (summary by Radosavljevic et al. (2002)
[PubMed 11827464] and Cao et al. (2007) [PubMed
17470428]).
组织表达
Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid.
细胞定位
Membrane; Single- pass type I membrane protein
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
