产品名称
NMI Rabbit Polyclonal Antibody (N-term)
别名
N-myc-interactor, Nmi, N-myc and STAT interactor, NMI
Human Gene ID
NP_004679.2
Human Swissprot No.
Q13287
特异性
This NMI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NMI.
背景介绍
NMYC interactor (NMI) encodes a protein that interacts
with NMYC and CMYC (two members of the oncogene Myc family), and
other transcription factors containing a Zip, HLH, or HLH-Zip
motif. The NMI protein also interacts with all STATs except STAT2
and augments STAT-mediated transcription in response to cytokines
IL2 and IFN-gamma. The NMI mRNA has low expression levels in all
human fetal and adult tissues tested except brain and has high
expression in cancer cell line-myeloid leukemias. [provided by
RefSeq].
组织表达
Expressed in adult spleen, liver, and kidney (PubMed:9781816). Expressed in fetal thymus, liver, placenta, spleen, lung, and kidney but not brain (PubMed:9781816). Expressed in macrophages (PubMed:29038465).
细胞定位
Cytoplasm. Nucleus. Secreted. Note=Cytoplasmic NMI localizes in punctate granular structures (PubMed:9781816, PubMed:10950963). Nuclear localization increased following IFN-alpha treatment (PubMed:9781816, PubMed:10950963). Extracelullar following secretion by macrophage (PubMed:29038465).
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
