产品名称
SEPT12 Rabbit Polyclonal Antibody (Center)
Human Gene ID
NP_001147930.1;NP_653206.2
Human Swissprot No.
Q8IYM1
特异性
This SEPT12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-244 amino acids from the Central region of human SEPT12.
背景介绍
Septins, such as SEPT12, are conserved GTP-binding
proteins that function as dynamic, regulatable scaffolds for the
recruitment of other proteins. They are involved in membrane
dynamics, vesicle trafficking, apoptosis, and cytoskeleton
remodeling, as well as infection, neurodegeneration, and neoplasia
(Hall et al., 2005 [PubMed 15915442]).
组织表达
Widely expressed. Expressed in lymph node.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Nucleus Cell projection, cilium, flagellum Note=At interphase, forms a filamentous structure in the cytoplasm During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus. Colocalized with SPAG4 at the nuclear periphery in round spermatids, at sperm neck in elongated spermatids and at midpiece regions in ejaculated spermatozoa.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
