产品名称
TMED10 Rabbit Polyclonal Antibody (C-term)
别名
Transmembrane emp24 domain-containing protein 10, 21 kDa transmembrane-trafficking protein, S31III125, S31I125, Tmp-21-I, Transmembrane protein Tmp21, p23, p24 family protein delta-1, p24delta1, p24delta, TMED10, TMP21
Human Gene ID
NP_006818.3
Human Swissprot No.
P49755
特异性
This TMED10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the C-terminal region of human TMED10.
背景介绍
This gene is a member of the EMP24/GP25L/p24 family and
encodes a protein with a GOLD domain. This type I membrane protein
is localized to the plasma membrane and golgi cisternae and is
involved in vesicular protein trafficking. The protein is also a
member of a heteromeric secretase complex and regulates the
complex's gamma-secretase activity without affecting its
epsilon-secretase activity. Mutations in this gene have been
associated with early-onset familial Alzheimer's disease. This gene
has a pseudogene on chromosome 8.
细胞定位
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q63584}; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000250|UniProtKB:Q63584}; Single-pass type I membrane protein. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
