产品名称
Mouse Shb Rabbit Polyclonal Antibody (C-term)
别名
SH2 domain-containing adapter protein B, Shb
Human Swissprot No.
Q6PD21
Mouse Gene ID
NP_001028478.1
特异性
This Mouse Shb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-95 amino acids from the C-terminal region of mouse Shb.
背景介绍
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells (By similarity).
组织表达
Expressed in heart, liver, brain and kidney (at protein level).
细胞定位
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
