产品名称
HIRIP3 Rabbit Polyclonal Antibody (Center)
别名
HIRA-interacting protein 3, HIRIP3
Human Gene ID
NP_001184252.1;NP_003600.2
Human Swissprot No.
Q9BW71
特异性
This HIRIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-316 amino acids from the Central region of human HIRIP3.
背景介绍
The HIRA protein shares sequence similarity with Hir1p
and Hir2p, the two corepressors of histone gene transcription
characterized in the yeast, Saccharomyces cerevisiae. The
structural features of the HIRA protein suggest that it may
function as part of a multiprotein complex. Recently, several
cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been
identified. In vitro, the HIRIP3 gene product binds HIRA, as well
as H2B and H3 core histones, indicating that a complex containing
HIRA-HIRIP3 could function in some aspects of chromatin and histone
metabolism.
组织表达
Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart
细胞定位
Nucleus. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
