产品名称
ORC6 Rabbit Polyclonal Antibody
蛋白名称
Origin recognition complex subunit 6
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y5N6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y5N6/entry
Mouse Swissprot No.
Q9WUJ8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WUJ8
免疫原
Synthesized peptide derived from human protein . at AA range: 160-240
特异性
ORC6 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010],
组织表达
Cervix,Epithelium,Testis,Whole embryo,
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能
function:Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ORC6 family.,subunit:ORC is composed of six subunits. Interacts with DBF4.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
