产品名称
SEPSECS Rabbit Polyclonal Antibody (C-term)
别名
O-phosphoseryl-tRNA(Sec) selenium transferase, Liver-pancreas antigen, LP, SLA-p35, SLA/LP autoantigen, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase, Sep-tRNA:Sec-tRNA synthase, SepSecS, Soluble liver antigen, SLA, UGA suppressor tRNA-associated protein, tRNA(Ser/Sec)-associated antigenic protein, SEPSECS, TRNP48
Human Gene ID
NP_058651.3
Human Swissprot No.
Q9HD40
特异性
This SEPSECS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-474 amino acids from the C-terminal region of human SEPSECS.
背景介绍
The 21st amino acid, selenocysteine (sec), is distinct
from other amino acids because it lacks its own tRNA synthetase and
is the only amino acid synthesized on its cognate tRNA. Synthesis
of sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) by
seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec),
which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase
(PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS
catalyzes the final step of sec synthesis by converting
O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using
selenophosphate as the selenium donor (Palioura et al., 2009
[PubMed 19608919]).
组织表达
Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells
纯化
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
