产品名称
S61A1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/29927
Human Swissprot No.
P61619
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P61619/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/53421
Mouse Swissprot No.
P61620
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P61620
Rat Gene Link
https://www.uniprot.org/uniprot/80843
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P61621
免疫原
Synthesized peptide derived from human S61A1 AA range: 333-383
特异性
This antibody detects endogenous levels of S61A1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008],
组织表达
Expressed in proximal and distal tubules in kidney (at protein level).
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Localizes exclusively in granular structures in the endoplasmic reticulum (ER). .
功能
function:Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins.,similarity:Belongs to the secY/SEC61-alpha family.,subunit:Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
